Eye protection should be worn whenever cryogenic liquids are handled. Where splashing is a possibility, face shields should be used. Appropriate gloves, shoes, and clothing should be worn. In case of a splash, immediately flood exposed areas and clothing with water. Avoid wearing watches, rings, bracelets, or other jewelry. Although many gases in the cryogenic range are not toxic (e.g. liquid nitrogen), they are all capable of causing asphyxiation by displacing the air necessary to support life. Therefore, they should be used only in well-ventilated areas. Venting should be provided to avoid quick and violent pressure changes when cryofluid vaporizes.

Handle combustible cryogens such as liquid hydrogen and liquid natural gas in the same way combustible gases are handled: provide ventilation, keep away from open flames and other ignition sources, prohibit smoking, and vent gases to a safe location. Exposed glass portions of the cryogenic container should be taped to minimize the flying glass hazard if the container should break or implode.